Artificial intelligence-enabled rapid and symptom-based medication recommendation system (COV-MED) for the COVID-19 patients

Main Article Content

Amit Shaha Surja
Md. Tariqul Islam Limon
Md. Janibul Alam Soeb
Md. Shoaib Arifin
Md. Meftaul Islam
Md. Shahidullah Kayshar
Md. Amirul Islam
Md. Mizanur Rahman
Md Abdul Malek
Faroque Md Mohsin
Mohammed Shah Jahan
Anupam Barua
Tanjima Binte Tofaz
Irin Sultana
Md. Fahad Jubayer

Abstract

In a general COVID-19 population in Cox’s Bazar, Bangladesh, we developed a medication recommendation system based on clinical information from the electronic medical record (EMR). Our goal was also to enable deep learning (DL) strategies to quickly assist physicians and COVID-19 patients by recommending necessary medications. The general demographic data, clinical symptoms, basic clinical tests, and drug information of 8953 patients were used to create a dataset. The learning model in this COVID-MED model was created using Keras (an open-source artificial neural network library) to solve regression problems. In this study, a sequential model was adopted. In order to improve the prediction capability and achieve global minima quickly and smoothly, the COVID-MED model incorporates an adaptive optimizer dubbed Adam. The model calculated a mean absolute error of 0.0037, a mean squared error of 0.000035, and a root mean squared error of 0.0059. The model predicts the output medications, such as injections or other oral medications, with around 99% accuracy. These findings show that medication can be predicted using information from the EMR. Similar models allow for patient-specific decision support to help prevent medication errors in diseases other than COVID-19.

Article Details

Section

Articles

How to Cite

1.
Artificial intelligence-enabled rapid and symptom-based medication recommendation system (COV-MED) for the COVID-19 patients. J Ideas Health [Internet]. 2022 Dec. 22 [cited 2025 Oct. 12];5(4). Available from: https://jidhealth.com/index.php/jidhealth/article/view/259

References

Yu KH, Beam AL, Kohane IS. Artificial intelligence in healthcare. Nature Biomedical Engineering. 2018;2(10):719-31. https://doi.org/10.1038/s41551-018-0305-z.

Gulshan V, Peng L, Coram M, Stumpe MC, Wu D, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R. Development and validation of a deep learning algorithm for detection of diabetic retinopathy in retinal fundus photographs. Jama. 2016;316(22):2402-10. http://doi.org/10.1001/jama.2016.17216

Jha S, Topol EJ. Adapting to artificial intelligence: radiologists and pathologists as information specialists. Jama.2016;316(22):2353-4. https://doi.org/10.1001/jama.2016.17438.

Debnath S, Barnaby DP, Coppa K, Makhnevich A, Kim EJ, Chatterjee S, Tóth V, Levy TJ, Paradis MD, Cohen SL, Hirsch JS. Machine learning to assist clinical decision-making during the COVID-19 pandemic. Bioelectronic medicine. 2020;6(1):1-8. https://doi.org/10.1186/s42234-020-00050-8

Alimadadi A, Aryal S, Manandhar I, Munroe PB, Joe B, Cheng X. Artificial intelligence and machine learning to fight COVID-19. Physiological Genomics. 2020;52(4):200-2. https://doi.org/10.1152/physiolgenomics.00029.2020

Haleem A, Javaid M, Khan IH. Current status and applications of artificial intelligence (AI) in medical field: An overview. Current Medicine Research and Practice. 2019;9(6):231-37. https://doi.org/10.1016/j.cmrp.2019.11.005

Alafif T, Tehame AM, Bajaba S, Barnawi A, Zia S. Machine and deep learning towards COVID-19 diagnosis and treatment: survey, challenges, and future directions. International Journal of Environmental Research and PublicHealth.2021;18(3):1117. https://doi.org/10.3390/ijerph18031117.

Song J, Wang Y, Tang S, Zhang Y, Chen Z, Zhang Z, Zhang T, Wu F. Local–Global Memory Neural Network for Medication Prediction. IEEE Transactions on Neural Networks and Learning Systems. 2020;32(4):1723-36. https://doi.org/10.1109/TNNLS.2020.2989364

OECD. OECD Glossary of Statistical Terms. 2008. p. 119. ISBN 978-92-64-025561.

Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?. The Lancet Respiratory Medicine. 2020;8(4):e21. https://doi.org/10.1016/S2213-2600(20)30116-8

Dodge Y. The Oxford Dictionary of Statistical Terms, 2003. OUP. ISBN 0-19-920613-9 (entry for normalization of scores).

Eijaz Allibhai (Medium, India). Building A Deep Learning Model using Keras. 2018. Available in: https://towardsdatascience.com/building-a-deep-learning-model-using-keras-1548ca149d37, (accessed 18 February 2022).

Da K. A method for stochastic optimization. arXiv preprint. 2014; arXiv:1412.6980. https://doi.org/10.48550/arXiv.1412.6980

Jamshidi M, Lalbakhsh A, Talla J, Peroutka Z, Hadjilooei F, Lalbakhsh P, Jamshidi M, La Spada L, Mirmozafari M, Dehghani M, Sabet A. Artificial intelligence and COVID-19: deep learning approaches for diagnosis and treatment. IEEE Access. 2020; 8:109581-95. https://doi.org/10.1109/ACCESS.2020.3001973

Ge Y, Tian T, Huang S, Wan F, Li J, Li S, Yang H, Hong L, Wu N, Yuan E, Cheng L. A data-driven drug repositioning framework discovered a potential therapeutic agent targeting COVID-19. BioRxiv. 2020. https://doi.org/10.1101/2020.03.11.986836

Zhavoronkov A, Zagribelnyy B, Zhebrak A, Aladinskiy V, Terentiev V, Vanhaelen Q, Bezrukov DS, Polykovskiy D, Shayakhmetov R, Filimonov A, Bishop M. Potential non-covalent SARS-CoV-2 3C-like protease inhibitors designed using generative deep learning approaches and reviewed by human medicinal chemist in virtual reality. Chemrxiv. 2020. https://doi.org/10.26434/chemrxiv.12301457.v1

Ong E, Wong MU, Huffman A, He Y. COVID-19 coronavirus vaccine design using reverse vaccinology and machine learning. Frontiers in Immunology. 2020;1581. https://doi.org/10.3389/fimmu.2020.01581

Senior AW, Evans R, Jumper J, Kirkpatrick J, Sifre L, Green T, Qin C, Žídek A, Nelson AW, Bridgland A, Penedones H. Improved protein structure prediction using potentials from deep learning. Nature. 2020;577(7792):706-10. https://doi.org/10.1038/s41586-019-1923-7

Murdoch TB, Detsky AS. The inevitable application of big data to health care. Jama. 2012;309(13):1351-52. https://doi.org/10.1001/jama.2013.393

Fokas AS, Cuevas-Maraver J, Kevrekidis PG. A quantitative framework for exploring exit strategies from the COVID-19 lockdown. Chaos, Solitons & Fractals. 2020;140:110244. https://doi.org/10.1016/j.chaos.2020.110244

Paul A, Chatterjee S, Bairagi N. Prediction on Covid-19 epidemic for different countries: Focusing on South Asia under various precautionary measures. Medrxiv. 2020. https://doi.org/10.1101/2020.04.08.20055095.

Zhou X, Liang W, Kevin I, Wang K, Shimizu S. Multi-modality behavioral influence analysis for personalized recommendations in health social media environment. IEEE Transactions on Computational Social Systems. 2019;6(5):888-97. https://doi.org/10.1109/TCSS.2019.2918285

Mei X, Lee HC, Diao KY, Huang M, Lin B, Liu C, Xie Z, Ma Y, Robson PM, Chung M, Bernheim A. Artificial intelligence–enabled rapid diagnosis of patients with COVID-19. Nature Medicine. 2020;26(8):1224-28. https://doi.org/10.1038/s41591-020-0931-3

Jiang F, Jiang Y, Zhi H, Dong Y, Li H, Ma S, Wang Y, Dong Q, Shen H, Wang Y. Artificial intelligence in healthcare: past, present and future. Stroke and Vascular Neurology. 2017;2(4). https://dx.doi.org/10.1136/svn-2017-000101

Rough K, Dai AM, Zhang K, Xue Y, Vardoulakis LM, Cui C, Butte AJ, Howell MD, Rajkomar A. Predicting inpatient medication orders from electronic health record data. Clinical Pharmacology & Therapeutics. 2020;108(1):145-54. https://doi.org/10.1002/cpt.1826

Zhao, M., Hoti, K., Wang, H., Raghu, A., & Katabi, D. Assessment of medication self-administration using artificial intelligence. Nature Medicine. 2021;27(4):727-35. https://doi.org/10.1038/s41591-021-01273-1