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Published: 2023-09-16

Exploring the determinant of flu vaccine hesitancy among Turkish population: a cross-sectional study

Department of Clinical Pharmacy, Faculty of Pharmacy
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Muhammed Yunus Bektay

Department of Clinical Pharmacy, Faculty of Pharmacy, Bezmialem Vakif University, 34093, Istanbul, Turkey

Abstract

Background: Although influenza is a contagious and widespread viral disease, its impact on public health is controlled by vaccination programs. However, anti-vaccination sentiment is also increasing in society. This study aims to explore the factors influencing influenza vaccine hesitancy.

Methods: Between November 2020 and January 2021, a cross-sectional observational survey was carried out in Turkey. To investigate the extent of vaccine hesitancy among individuals, an online questionnaire was created using Google Forms. Data were collected using an exponential non-discriminative snowball sampling technique. Besides internal consistency reliability, chi-square was performed. Statistical significance was defined as p < 0.05.

Results: This research encompassed a cohort of 172 respondents, with an average age of 53.5±14.3 years within the total sample. Most participants (126, 73.25%) were above 45. The participant group was predominantly female (93, 54.1%), and most had achieved a high school or university education (117, 66.2%). Out of the participants, 123 individuals (71.5%) reported having a chronic ailment. Among the 172 participants, 118 (68.6%) exhibited no reluctance to receive the influenza vaccine, while 54 (31.4%) expressed vaccine hesitancy. There was a notable statistically significant distinction in the level of knowledge regarding influenza vaccines (p<0.001, χ²= 20.482).

Conclusion: Lack of information, perceived harms, lack of trust in pharmaceutical companies, and experiences are among the most important determinants of anti-vaccination. Pharmacists may have a potential role in the leading part of the healthcare team in the fight against anti-vaccination in the community.



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References

  1. World Health Organization. Influenza seasonal [Internet].. Available from: https://www.who.int/health-topics/influenza-seasonal?gclid=CjwKCAjw29ymBhAKEiwAHJbJ8kOoxHf4VIw5PAZpgiEECx-M2DbRqzj2C68eTFc-7BdHS0jT0AuXnhoCiHQQAvD_BwE#tab=tab_1.
  2. Schmid P, Rauber D, Betsch C, Lidolt G, Denker M-L. Barriers of Influenza Vaccination Intention and Behavior - A Systematic Review of Influenza Vaccine Hesitancy, 2005 - 2016. PLoS One. 2017;12(1):e0170550. DOI: 10.1371/journal.pone.0170550.
  3. World Health Organization. The Global Action Plan for Influenza Vaccines: report of the tenth meeting of the Advisory Group of the WHO Global Action Plan for Influenza Vaccines [Internet]. Geneva: World Health Organization; Available from: https://apps.who.int/iris/handle/10665/182733.
  4. Kumar S, Shah Z, Garfield S. Causes of Vaccine Hesitancy in Adults for the Influenza and COVID-19 Vaccines: A Systematic Literature Review. Vaccines. 2022 Sep;10(9). DOI: 10.3390/vaccines10091005.
  5. Centers for Disease Control and Prevention. Vaccine Effectiveness: How Well Do Flu Vaccines Work? [Internet]. Available from: https://www.cdc.gov/flu/vaccines-work/vaccineeffect.htm.
  6. Olivera Mesa D, Hogan AB, Watson OJ, Charles GD, Hauck K, Ghani AC, et al. Modeling the impact of vaccine hesitancy in prolonging the need for Non-Pharmaceutical Interventions to control the COVID-19 pandemic. Commun Med. 2022;2:14. DOI: 10.1038/s43856-022-00083-3.
  7. Larson HJ, Jarrett C, Eckersberger E, Smith DMD, Paterson P. Understanding vaccine hesitancy around vaccines and vaccination from a global perspective: a systematic review of published literature, 2007-2012. Vaccine. 2014 Apr;32(19):2150–9. DOI: 10.1016/j.vaccine.2014.01.081.
  8. Jarrett C, Wilson R, O’Leary M, Eckersberger E, Larson HJ. Strategies for addressing vaccine hesitancy - A systematic review. Vaccine. 2015 Aug;33(34):4180–90. DOI: 10.1016/j.vaccine.2015.04.040.
  9. Strelitz B, Gritton J, Klein EJ, Bradford MC, Follmer K, Zerr DM, et al. Parental vaccine hesitancy and acceptance of seasonal influenza vaccine in the pediatric emergency department. Vaccine. 2015 Apr;33(15):1802–7. DOI: 10.1016/j.vaccine.2015.01.087.
  10. MacDonald NE. Vaccine hesitancy: Definition, scope and determinants. Vaccine. 2015 Aug;33(34):4161–4. DOI: 10.1016/j.vaccine.2015.04.036.
  11. Osterholm MT, Kelley NS, Sommer A, Belongia EA. Efficacy and effectiveness of influenza vaccines: a systematic review and meta-analysis. Lancet Infect Dis. 2012 Jan;12(1):36–44. DOI: 10.1016/S1473-3099(11)70295-X.
  12. Yuen CYS, Tarrant M. Determinants of uptake of influenza vaccination among pregnant women - a systematic review. Vaccine. 2014 Aug;32(36):4602–13. DOI: 10.1016/j.vaccine.2014.06.055.
  13. Kynčl J, Liptáková M, Košťálová J, Malý M, Křížová M, Heřman H, et al. Vaccination against influenza in pregnant women in a maternity hospital in the Czech Republic in the season 2020-2021. BMC Public Health. 2023 May;23(1):1029. DOI: 10.1186/s12889-023-13001-3.
  14. Galanis P, Katsiroumpa A, Vraka I, Siskou O, Konstantakopoulou O, Katsoulas T, et al. Seasonal Influenza Vaccine Intention among Nurses Who Have Been Fully Vaccinated against COVID-19: Evidence from Greece. Vaccines. 2023 Jan;11(1). DOI: 10.3390/vaccines11010076.
  15. Nagata JM, Hernández-Ramos I, Kurup AS, Albrecht D, Vivas-Torrealba C, Franco-Paredes C. Social determinants of health and seasonal influenza vaccination in adults ≥65 years: a systematic review of qualitative and quantitative data. BMC Public Health. 2013 Apr;13:388. DOI: 10.1186/1471-2458-13-388.
  16. Addario A, Célarier T, Bongue B, Barth N, Gavazzi G, Botelho-Nevers E. Impact of influenza, herpes zoster, and pneumococcal vaccinations on the incidence of cardiovascular events in subjects aged over 65 years: a systematic review. GeroScience. 2023 Jun;1–29. DOI: 10.1007/s11357-023-00456-y.
  17. Prematunge C, Corace K, McCarthy A, Nair RC, Pugsley R, Garber G. Factors influencing pandemic influenza vaccination of healthcare workers--a systematic review. Vaccine. 2012 Jul;30(32):4733–43. DOI: 10.1016/j.vaccine.2012.05.018.
  18. Sökmen S, Ünal E. Evaluation of the knowledge, attitudes, vaccine hesitancy, and behaviors of anesthesia technicians on adult vaccination. Journal of Ideas in Health. 2022 Jul. 19;5(Special1):707-15. DOI: 10.47108/jidhealth.vol5.issspecial1.224.
  19. Yeung MPS, Lam FLY, Coker R. Factors associated with the uptake of seasonal influenza vaccination in adults: a systematic review. J Public Health (Oxf). 2016 Dec;38(4):746–53. DOI: 10.1093/pubmed/fdw099.
  20. Salam M, Honein-AbouHaidar G. Determinants of influenza and COVID-19 vaccine intent or uptake in Lebanon: a scoping review of the literature. BMC Infect Dis. 2023 Aug;23(1):511. DOI: 10.1186/s12879-023-06797-6.
  21. Bektay MY, Sancar M, Okyaltirik F, Durdu B, Izzettin FV. Investigation of drug-related problems in patients hospitalized in chest disease wards: A randomized controlled trial. Front Pharmacol. 2023 Jan;13:5078. DOI: 10.3389/fphar.2022.5078.
  22. Sümbül-Şekerci B, Bildik Ö, Bektay MY, İzzettin FV. Attitudes of medicine, pharmacy, and dentistry students about psychostimulant use to enhance cognition. Int J Clin Pract. 2021 Oct;75(10):e14608. DOI: 10.1111/ijcp.14608.
  23. Okuyan B, Bektay MY, Kingir ZB, Save D, Sancar M. Community pharmacy cognitive services during the COVID-19 pandemic: A descriptive study of practices, precautions taken, perceived enablers and barriers and burnout. Int J Clin Pract. 2021;e14834. DOI: 10.1111/ijcp.14834.
  24. Atkins K, van Hoek AJ, Watson C, Baguelin M, Choga L, Patel A, et al. Seasonal influenza vaccination delivery through community pharmacists in England: evaluation of the London pilot. BMJ Open. 2016 Feb;6(2):e009739. DOI: 10.1136/bmjopen-2015-009739.
  25. The Pharmaceutical Group of the European Union (PGEU). European Union Communicable Diseases and Vaccination 2019. DOI: Not applicable.
  26. Isenor JE, Edwards NT, Alia TA, Slayter KL, MacDougall DM, McNeil SA, et al. Impact of pharmacists as immunizers on vaccination rates: A systematic review and meta-analysis. Vaccine. 2016 Nov;34(47):5708–23. DOI: 10.1016/j.vaccine.2016.10.001.
  27. International Pharmaceutical Federation (FIP). An overview of pharmacy's impact on immunization coverage: a global survey. [Internet]. 2020. Available from: https://www.fip.org/file/4751.
  28. Sharma A, Minh Duc NT, Luu Lam Thang T, Nam NH, Ng SJ, Abbas KS, et al. A Consensus-Based Checklist for Reporting of Survey Studies (CROSS). J Gen Intern Med. 2021 Oct;36(10):3179–87. DOI: 10.1007/s11606-021-06998-3.
  29. ECDC (European Centre for Disease Prevention and Control). Seasonal influenza vaccination and antiviral use in EU/EEA Member States [Internet]. 2018. Available from: https://www.ecdc.europa.eu/sites/default/files/documents/Seasonal-influenza-antiviral-use-EU-EEA-Member-States-December-2018_0.pdf.
  30. Galistiani GF, Matuz M, Matuszka N, Doró P, Schváb K, Engi Z, et al. Determinants of influenza vaccine uptake and willingness to be vaccinated by pharmacists among the active adult population in Hungary: a cross-sectional exploratory study. BMC Public Health. 2021 Mar;21(1):521. DOI: 10.1186/s12889-021-10405-2.
  31. Endrich MM, Blank PR, Szucs TD. Influenza vaccination uptake and socioeconomic determinants in 11 European countries. Vaccine. 2009 Jun;27(30):4018–24. DOI: 10.1016/j.vaccine.2009.04.053.
  32. Tessier E, Warburton F, Tsang C, Rafeeq S, Boddington N, Sinnathamby M, et al. Population-level factors predicting variation in influenza vaccine uptake among adults and young children in England, 2015/16 and 2016/17. Vaccine. 2018 May;36(23):3231–8. DOI: 10.1016/j.vaccine.2018.04.054.
  33. Dyda A, Karki S, Hayen A, MacIntyre CR, Menzies R, Banks E, et al. Influenza and pneumococcal vaccination in Australian adults: a systematic review of coverage and factors associated with uptake. BMC Infect Dis. 2016 Sep;16(1):515. DOI: 10.1186/s12879-016-1845-x.
  34. Ciblak MA. Influenza vaccination in Turkey: prevalence of risk groups, current vaccination status, factors influencing vaccine uptake and steps taken to increase vaccination rate. Vaccine. 2013 Jan;31(3):518–23. DOI: 10.1016/j.vaccine.2012.10.081.
  35. Goktas O, Can FE, Yakar B, Ercan I, Akalin EH. Seasonal influenza vaccine awareness and factors affecting vaccination in Turkish Society. Pakistan J Med Sci. 2022;38(4Part-II):893–9. DOI: 10.12669/pjms.38.4.4515.
  36. Korkmaz N, Nazik S, Gümüştakım RŞ, Uzar H, Kul G, Tosun S, et al. Influenza vaccination rates, knowledge, attitudes and behaviors of healthcare workers in Turkey: A multicentre study. Int J Clin Pract. 2021 Jan;75(1):e13659. DOI: 10.1111/ijcp.13659.
  37. Alqahtani AS, Althobaity HM, Al Aboud D, Abdel-Moneim AS. Knowledge and attitudes of Saudi populations regarding seasonal influenza vaccination. J Infect Public Health. 2017;10(6):897–900. DOI: 10.1016/j.jiph.2016.07.003.
  38. Smith LE, Amlôt R, Weinman J, Yiend J, Rubin GJ. A systematic review of factors affecting vaccine uptake in young children. Vaccine. 2017 Oct;35(45):6059–69. DOI: 10.1016/j.vaccine.2017.08.043.
  39. International Pharmaceutical Federation (FIP). COVID-19 pandemic: Guidelines for pharmacists and the pharmacy workforce [Internet]. The Hague, Netherlands; Available from: https://www.fip.org/files/content/priority-areas/coronavirus/COVID-19-Guidelines-for-pharmacists-and-the-pharmacy-workforce.pdf. DOI: Not applicable.
  40. Shen AK, Tan ASL. Trust, influence, and community: Why pharmacists and pharmacies are central for addressing vaccine hesitancy. J Am Pharm Assoc (2003). 2022;62(1):305–8. DOI: 10.1016/j.japh.2021.09.020.


How to Cite

1.
Bektay MY, Ulaş MH. Exploring the determinant of flu vaccine hesitancy among Turkish population: a cross-sectional study . jidhealth [Internet]. 2023 Sep. 16 [cited 2024 Jun. 20];6(3):931-8. Available from: https://jidhealth.com/index.php/jidhealth/article/view/302