Abstract
Background: Recognizing the preoperatively and intraoperatively factors can aid surgeons in making timely decisions to shift from laparoscopic cholecystectomy (LC) to open cholecystectomy (OC). This study aims to identify the main factors leading to LC conversion to OC among Iraqi patients.
Methods: One-year prospective research was performed using cross-sectional design between 1st April, 2023, and 3oth March, 2024, at Alkalis General Public Hospital and Al Hayat Private Hospital, Diyala, Iraq. Pre and intraoperative data were collected from the planned LC surgeries including demographics, medical history, laboratory and Ultrasound findings. Descriptive and bivariate analysis was carried out to compare variables between patients undergoing LC and those requiring conversion to OC.
Results: Out of 172 LC patients (mean age 48.28±12.62), 52.9% were female, 55.8% obese, 50.6% aged 49+, 23.3% diabetic, and 19.8% had emergency cholecystectomy; 15 (8.7%) required conversion to open surgery. The conversion group was mainly men (66.7% vs. 46.5%, P = 0.001) and older (73.3% vs. 48.4% aged 49+, P = 0.003). Obesity (60.0% vs. 55.4%, P = 0.005) and diabetes (53.3% vs. 20.4%, P < 0.001) were more common. Public hospital referrals were higher (86.7% vs. 52.2%, P < 0.001). Elevated total bilirubin, direct bilirubin, and alkaline phosphatase levels were significant predictors of conversion to OC. Adhesions in Calot's triangle (20.0% vs. 13.4%, P = 0.021) were more common in the conversion group, along with unclear anatomy, thick gallbladder wall, bleeding, stone and bile spillage, and cystic duct injury.
Conclusion: In conclusion, out of 172 LC patients, 15 (8.7%) required conversion to open surgery, predominantly older men with higher obesity, diabetes, and elevated bilirubin and alkaline phosphatase levels, and more adhesions in Calot's triangle.
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References
- Mannam R, Sankara Narayanan R, Bansal A, Yanamaladoddi VR, Sarvepalli SS, Vemula SL, Aramadaka S. Laparoscopic Cholecystectomy Versus Open Cholecystectomy in Acute Cholecystitis: A Literature Review. Cureus. 2023 Sep 21;15(9):e45704. doi: 10.7759/cureus.45704.
- Magnano San Lio R, Barchitta M, Maugeri A, Quartarone S, Basile G, Agodi A. Preoperative Risk Factors for Conversion from Laparoscopic to Open Cholecystectomy: A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2022 Dec 27;20(1):408. doi: 10.3390/ijerph20010408. PMID: 36612732; PMCID: PMC9819914.
- Hu ASY, Menon R, Gunnarsson R, de Costa A. Risk factors for conversion of laparoscopic cholecystectomy to open surgery - A systematic literature review of 30 studies. Am J Surg. 2017 Nov;214(5):920-930. doi: 10.1016/j.amjsurg.2017.07.029.
- Sharma D, Kishore KN, Gondu GR, Thumma VM, Gunturi SV, Reddy JM, et al. Predictive factors for conversion from laparoscopic to open cholecystectomy: an institutional study. Int Surg J. 2018;5(8):2894-8. DOI: https://doi.org/10.18203/2349-2902.isj20183210.
- Utsumi M, Aoki H, Kunitomo T, Mushiake Y, Yasuhara I, Taniguchi F, Arata T, Katsuda K, Tanakaya K, Takeuchi H. Preoperative Risk Factors for Conversion of Laparoscopic Cholecystectomy to Open Cholecystectomy and the Usefulness of the 2013 Tokyo Guidelines. Acta Med Okayama. 2017 Oct;71(5):419-425. doi: 10.18926/AMO/55440.
- Sakpal SV, Bindra SS, Chamberlain RS. Laparoscopic cholecystectomy conversion rates two decades later. JSLS. 2010 Oct-Dec;14(4):476-483. doi: 10.4293/108680810X12924466007926.
- Ábrahám S, Németh T, Benkő R, Matuz M, Váczi D, Tóth I, Ottlakán A, Andrási L, Tajti J, Kovács V, Pieler J, Libor L, Paszt A, Simonka Z, Lázár G. Evaluation of the conversion rate as it relates to preoperative risk factors and surgeon experience: a retrospective study of 4013 patients undergoing elective laparoscopic cholecystectomy. BMC Surg. 2021 Mar 20;21(1):151. doi: 10.1186/s12893-021-01152-z.
- Nassar AHM, Zanati HE, Ng HJ, Khan KS, Wood C. Open conversion in laparoscopic cholecystectomy and bile duct exploration: subspecialisation safely reduces the conversion rates. Surg Endosc. 2022 Jan;36(1):550-558. doi: 10.1007/s00464-021-08316-1.
- Staubli SM, Maloca P, Kuemmerli C, Kunz J, Dirnberger AS, Allemann A, Gehweiler J, Soysal S, Droeser R, Däster S, Hess G, Raptis D, Kollmar O, von Flüe M, Bolli M, Cattin P. Magnetic resonance cholangiopancreatography enhanced by virtual reality as a novel tool to improve the understanding of biliary anatomy and the teaching of surgical trainees. Front Surg. 2022 Aug 12;9:916443. doi: 10.3389/fsurg.2022.916443.
- Coelho JCU, Dalledone GO, Schiel W, Berbardin JP, Claus CMP, Matias JEF, Freitas ACT. Does male gender increase the risk of laparoscopic cholecystectomy? Arq Bras Cir Dig. 2019 Aug 26;32(2):e1438. doi: 10.1590/0102-672020190001e1438.
- Nascimento JHFD, Tomaz SC, Souza-Filho BM, Vieira ATS, Andrade AB, Gusmão-Cunha A. A population study on gender and ethnicity differences in gallbladder disease in Brazil. Arq Bras Cir Dig. 2022 Jun 17;35:e1652. doi: 10.1590/0102-672020210002e1652.
- Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver. 2012 Apr;6(2):172-87. doi: 10.5009/gnl.2012.6.2.172. Epub 2012 Apr 17.
- Parra-Landazury NM, Cordova-Gallardo J, Méndez-Sánchez N. Obesity and Gallstones. Visc Med. 2021 Oct;37(5):394-402. doi: 10.1159/000515545.
- Hendrickson M, Naparst TR. Abdominal surgical emergencies in the elderly. Emerg Med Clin North Am. 2003 Nov;21(4):937-69. doi: 10.1016/s0733-8627(03)00072-5.
- Shaffer EA. Epidemiology and risk factors for gallstone disease: has the paradigm changed in the 21st century? Curr Gastroenterol Rep. 2005 May;7(2):132-40. doi: 10.1007/s11894-005-0051-8.
- Elmehdawi R, Elmajberi S, Behieh A, Elramli A. Prevalence of Gall Bladder Stones among Type 2 Diabetic Patients in Benghazi Libya: A Case-control Study. Libyan J Med. 2009 Mar 1;4(1):27-30. doi: 10.4176/081122.
- Almobarak AO, Jervase A, Fadl AA, Garelnabi NIA, Hakem SA, Hussein TM, Ahmad AAA, Ahmed ISE, Badi S, Ahmed MH. The prevalence of diabetes and metabolic syndrome and associated risk factors in Sudanese individuals with gallstones: a cross sectional survey. Transl Gastroenterol Hepatol. 2020 Apr 5;5:14. doi: 10.21037/tgh.2019.10.09.
- Wiggins T, Markar SR, MacKenzie H, Faiz O, Mukherjee D, Khoo DE, Purkayastha S, Beckingham I, Hanna GB. Optimum timing of emergency cholecystectomy for acute cholecystitis in England: population-based cohort study. Surg Endosc. 2019 Aug;33(8):2495-2502. doi: 10.1007/s00464-018-6537-x.
- Pal A, Ahluwalia PS, Sachdeva K, Kashyap R. Intraoperative scoring system to assess the difficult laparoscopic cholecystectomy: a prospective study from a tertiary care centre. Cureus. 2023 Mar 4;15(3):e35767. doi: 10.7759/cureus.35767.
- Bazoua G, Tilston MP. Male gender impact on the outcome of laparoscopic cholecystectomy. JSLS. 2014 Jan-Mar;18(1):50-4. doi: 10.4293/108680813X13693422518830.
- Dastan I, Al-samarraie MAM, Ali Jadoo SA. Female doctors are more emotionally exhausted than their male counterparts in Iraq. Journal of Ideas in Health. 2019 Jun. 29 ;2(1):75-9. doi: 10.47108/jidhealth.vol2.iss1.18.
- Yaseen SM, Ali Jadoo SA, Abdullah AA, Mahmood AS, Abd Al-wahaab WN. Predictive factors of successful extracorporeal shockwave lithotripsy (ESWL) for renal stones: evidence of retrospective study. Journal of Ideas in Health. 2019 May 17;2(1):60-4. doi: 10.47108/jidhealth.vol2.iss1.11.
- Cullinane C, Fullard A, Croghan SM, Elliott JA, Fleming CA. Effect of obesity on perioperative outcomes following gastrointestinal surgery: meta-analysis. BJS Open. 2023 Jul 10;7(4):zrad026. doi: 10.1093/bjsopen/zrad026.
- Ratheesh R, Ulrich MT, Ghozy S, Al-Jaboori M, Nayak SS. The association between diabetes and gallstones: a nationwide population-based cohort study. Prz Gastroenterol. 2023;18(3):292-299. doi: 10.5114/pg.2023.131395.
- Davenport DL, Henderson WG, Khuri SF, Mentzer RM Jr. Preoperative risk factors and surgical complexity are more predictive of costs than postoperative complications: a case study using the National Surgical Quality Improvement Program (NSQIP) database. Ann Surg. 2005 Oct;242(4):463-8; discussion 468-71. doi: 10.1097/01.sla.0000183348.15117.ab.
- Alhusseiny AH, Latif II, Ali Jadoo SA. Covid-19 in Iraq: an estimated cost to treat patients at a private clinic. Journal of Ideas in Health. 2021 Mar. 18 ;4(1):304-6. doi: 10.47108/jidhealth.vol4.iss1.82.
- Amin A, Haider MI, Aamir IS, Khan MS, Khalid Choudry U, Amir M, Sadiq A. Preoperative and Operative Risk Factors for Conversion of Laparoscopic Cholecystectomy to Open Cholecystectomy in Pakistan. Cureus. 2019 Aug 20;11(8):e5446. doi: 10.7759/cureus.5446.
- Bhandari TR, Khan SA, Jha JL. Prediction of difficult laparoscopic cholecystectomy: An observational study. Ann Med Surg (Lond). 2021 Nov 14;72:103060. doi: 10.1016/j.amsu.2021.103060.
- Ali Sapmaz A, Karaca AS. Risk factors for conversion to open surgery in laparoscopic cholecystectomy: a single center experience. Turk J Surg 2021; 37 (1): 28-32. DOI: 10.47717/turkjsurg.2020.4734.
- Mohammed AS, Hussein HA, Ali Jadoo SA, Alsalaumy MH, Hassan LF, Hussein MR. Liver Stiffness and Fibrosis Used as Early Diagnosis of Patients with Chronic Liver Disease in A Retrospective Cross-Sectional Study. Journal of Angiotherapy.2024. 8(4) 1-7. https://doi.org/10.25163/angiotherapy.849585.
- Griniatsos J. Factors predisposing to conversion from laparoscopic to open cholecystectomy. Ann Laparosc Endosc Surg 2018;3:12:1-11. doi: 10.21037/ales.2018.01.0.
- Khan I, Yadav P, Saran RK, Sharma S, Sharma AK. A Study of the Degree of Gall Bladder Wall Thickness and Its Impact on Patients Undergoing Laparoscopic Cholecystectomy. Cureus. 2023 May 14;15(5):e38990. doi: 10.7759/cureus.38990.
- Suuronen S, Kivivuori A, Tuimala J, Paajanen H. Bleeding complications in cholecystectomy: a register study of over 22,000 cholecystectomies in Finland. BMC Surg. 2015 Aug 13;15:97. doi: 10.1186/s12893-015-0085-2.
- Virupaksha S. Consequences of spilt gallstones during laparoscopic cholecystectomy. Indian J Surg. 2014 Apr;76(2):95-9. doi: 10.1007/s12262-012-0600-y.
- Salem AA, Salama RS, Abd El-Latif ME, El-Gazzar AE. Retrospective Study of Common Bile Duct Injury after Laparoscopic Cholecystectomy. Benha Journal of Applied Sciences (BJAS). 2021; 6(1): 89-96.
- Jaber A, Muhammed A. Postoperative satisfaction and perception among laparoscopic cholecystectomy patients in Diyala Province, Iraq. Journal of Ideas in Health. 2024 Jun. 30 ;7(3):1073-80. doi: 10.47108/jidhealth.vol7.iss3.347.