Abstract
Background: Cardiovascular reactivity to stress was revealed to be a predictor of future cardiovascular risk. A positive family history of hypertension is an important risk factor for the development of hypertension in the children of hypertensive parents. We applied cold pressor test (CPT) to measure heart rate variability (HRV) with the objective to assess the cardiovascular autonomic response to stress.
Methods: A case-control study was conducted between from December 2022 to November 2023 at the department of Physiology, Government Medical College, Kota in India. A total of 70 Cases and 70 Controls underwent to CPT technique to evaluate the autonomic function to stress. Descriptive and bivariate analysis including Mann-Whitney U-and ANOVA tests were performed.
Results: In this study, the mean ± SD values of HRV in control group before CPT was 79 ± 13, during CPT was 81 ± 11 and after CPT was 77 ± 9. The HR in control group was increased during CPT and the level decreased after CPT. The HRV level in control group was statistically significantly different before CPT, during CPT and after CPT, and p= 0.04.
Conclusion: The autonomic measurements were found higher in offspring of hypertensive parents (OHTPs) compared to offspring of normotensive parents (ONHTPs). The offspring of hypertensive parents have higher chances of future development of hypertension than the offspring of normotensive parents.
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References
- Millar JP, Paashis A, McCartney N. Isometric handgrip effects on hypertension. Curr Hypertens Rev. 2009;5(1):54-60.
- Gupta R. Trends in hypertension epidemiology in India. J Hum Hypertens. 2004;18:73-8.
- Choudary S, et al. Study of anthropometric parameters in young healthy individuals having a parental history of hypertension: A study conducted on college-going adolescents. Int J Biol Med Res. 2011;2(2):547-50.
- Beauchaine TP, Thayer JF. Heart rate variability as a transdiagnostic biomarker of psychopathology. Int J Psychophysiol. 2015;98(2):338-50. doi: 10.1016/j.ijpsycho.2015.08.004. Epub 2015 Aug 11. PMID: 26272488.
- Jarczok MN, Weimer K, Braun C, Williams DP, et al. Heart rate variability in the prediction of mortality: A systematic review and meta-analysis of healthy and patient populations. Neurosci Biobehav Rev. 2022;143:104907. doi: 10.1016/j.neubiorev.2022.104907. Epub 2022 Oct 13. PMID: 36243195.
- Kidwell M, Ellenbroek BA. Heart and soul: heart rate variability and major depression. Behav Pharmacol. 2018;29(3):152-64. doi: 10.1097/FBP.0000000000000387. PMID: 29543649.
- Glasser SP. Hypertension syndrome and cardiovascular events: High blood pressure is only one risk factor. Postgrad Med. 2001;110(5):29-36. doi: 10.1080/00325481.2001.11445493. PMID: 11727651.
- Moinuddin A, Saini S, Goel A, Mishra R, Bajpai A. Derangement in autonomic functions with elevated blood pressure. ERA’s J Med Res. 2016;3(2):1-6.
- Ranasinghe P, Cooray DN, Jayawardena R, Prasad K. The influence of family history of hypertension on disease prevalence and associated metabolic risk factors among Sri Lankan adults. BMC Public Health. 2015;15:576. doi: 10.1186/s12889-015-1927-7. PMID: 26092387; PMCID: PMC4475303.
- Rathi P, Agarwal V, Kumar A. Sympathetic hyperactivity in children of hypertensive parents. Ann Neurosci. 2013;20(1):4-6. doi: 10.5214/ans.0972.7531.200103. PMID: 25206000; PMCID: PMC4117100.
- Pal GK, Adithan C, Amudharaj D, Dutta TK, Pal P, Nandan PG, Nanda N. Assessment of sympathovagal imbalance by spectral analysis of heart rate variability in prehypertensive and hypertensive patients in the Indian population. Clin Exp Hypertens. 2011;33:478-83.
- Zhao Q, Bazzano LA, Cao J, Li J, Chen J, Huang J, et al. Reproducibility of blood pressure response to the cold pressor test: The Gen Salt Study. Am J Epidemiol. 2012;176(7):91-8. PMID: 23035148.
- Dutta B, Bora B. Study of pulmonary function tests in response to localized cold stimuli in age group between 19–30 years of Guwahati City. Int J Res Med Sci. 2017;5(7):3107–10. doi: 10.18203/2320-6012.ijrms20172996.
- Rothwell PM, et al. Limitations of the usual blood-pressure hypothesis and importance of variability, instability, and episodic hypertension. Lancet. 2010;375(9718):938-48. doi: 10.1016/S0140-6736(10)60309-1. PMID: 20226991.
- Milliani A. Heart rate variability: From bench to bedside. Eur J Intern Med. 2005;16(1):12-20. doi: 10.1016/j.ejim.2004.06.016.
- Pagani M, Lucini D. Autonomic dysregulation in essential hypertension: Insight from heart and arterial blood pressure variability. Auton Neurosci. 2001;90:76-82.
- Task Force Committee, et al. Heart rate variability: Standards of measurement, physiological interpretation, and clinical use. Eur Heart J. 1996;17:354-81.
- McGinley JJ, Friedman BH. Autonomic responses to lateralized cold pressor and facial cooling tasks. Psychophysiology. 2015;52(3):416-24. doi: 10.1111/psyp.12332. Epub 2014 Sep 24. PMID: 25250478.
- Singh S, Shukla N, Shukla A. Association of heart rate variability and C-reactive protein in patients with depression. J Family Med Prim Care. 2024;13:191-8.
- Wang Y, Zhao X, O’Neil A, Turner A, Liu X, Berk M. Altered cardiac autonomic nervous function in depression. BMC Psychiatry. 2013;13:187.
- Jangpangi D, Mondal S, Bandhu R, Kataria D, Gandhi A. Alteration of heart rate variability in patients of depression. J Clin Diagn Res. 2016;10(12):4-6. PMID: 28208852; PMCID: PMC5296425.
- Kapoor A, Singh S. To study autonomic variability in offspring of hypertensive parents in Lucknow using cold pressor test. Indian J Clin Anat Physiol. 2019;6(2):139-43. doi: 10.18231/j.ijcap.2019.032.
- Tamilselvan K, Nirmala N, Latha R, Vijayasri SG. Assessment of autonomic functions in the normotensive offspring of hypertensive parents. Int J Physiol. 2018;6(1):112. doi: 10.5958/2320-608X.2018.00023.9.
- Keller-Ross ML, Cunningham HA, Carter JR. Impact of age and sex on neural cardiovascular responsiveness to cold pressor test in humans. Am J Physiol Regul Integr Comp Physiol. 2020;319(3):288–95. doi: 10.1152/ajpregu.00045.2020.
