Factors associated with hepatitis B vaccination among nursing and midwifery students at the university for development studies, Ghana: an analytical cross-sectional study Determinants of HBV Testing and Vaccination

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Published: 2026-10-31
DOI: https://doi.org/10.47108/jidhealth.Vol9.Iss5.462
Keywords:
Hepatitis B, Testing, Vaccination, Nursing and Midwifery Students, Structural equation Modelling, Ghana

Main Article Content

Yakubu Abubakari Siddique
School of Public Health and Allied Sciences, Catholic University of Ghana, Sunyani-Fiapre, Ghana. Department of Internal Medicine, Dialysis Unit, Tamale Teaching Hospital, Northern Region, Tamale-Ghana.
Sabina Ampon-Wireko
School of Public Health and Allied Sciences, Catholic University of Ghana, Sunyani-Fiapre, Ghana.
Samuel Yaw Opoku
School of Public Health and Allied Sciences, Catholic University of Ghana, Sunyani-Fiapre, Ghana.
Alhassan Basour Adam
Department of General Nursing, School of Nursing and Midwifery, University for Development Studies, Tamale-Ghana.
Paulina Kaba
School of Nursing and Midwifery, Catholic University of Ghana, Sunyani-Fiapre, Ghana.
Enoch Weikem Weyori
School of Public Health and Allied Sciences, Catholic University of Ghana, Sunyani-Fiapre, Ghana.

Abstract

Background: Hepatitis B virus (HBV) remains an important occupational health concern for healthcare workers, including nursing and midwifery students who may be exposed to blood and body fluids during clinical training. This study aims to assess the associations of attitude, HBV testing and socioeconomic conditions with hepatitis B vaccination among nursing and midwifery students at the University for Development Studies (UDS), Ghana.


Methods: An analytical cross-sectional study was conducted among nursing and midwifery students at UDS, Tamale, in June 2023. Of 350 students approached, 306 completed a structured questionnaire. Data were analyzed using partial least squares structural equation modelling (PLS-SEM) in SmartPLS 4.3.1 and complementary ordinary least-squares regression in SPSS. The measurement model was assessed using indicator loadings, Cronbach's alpha, composite reliability, average variance extracted (AVE), and the Fornell-Larcker criterion.


Results: Of the 306 respondents, 85.0% had ever tested for HBV, 79.4% reported receiving at least one vaccine dose, and 62.7% reported completing three doses. The PLS-SEM model showed positive associations of attitude (β=0.353, p<0.001), HBV testing (β=0.301, p<0.001), and socioeconomic conditions (β=0.291, p<0.001) with the HBV vaccination construct and explained 76.2% of its variance (R²=0.762). In the complementary regression analysis, the main-effects model explained 72.5% of the variance in vaccination (R²=0.725). Adding interaction terms increased R² to 0.728 (ΔR²=0.003); both HBV testing×socioeconomic conditions (β=0.213, p<0.001) and attitude×HBV testing (β=0.311, p<0.001) were positively associated with vaccination.


Conclusion: Attitude, HBV testing and socioeconomic conditions were positively associated with hepatitis B vaccination among the participating students. Interventions that improve access to HBV testing and vaccination and strengthen occupational-risk awareness may support higher vaccination uptake. Because of the cross-sectional design, these associations should not be interpreted as causal effects.

Article Details

Issue

Vol. 9 No. 5 (2026)

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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

1.
Factors associated with hepatitis B vaccination among nursing and midwifery students at the university for development studies, Ghana: an analytical cross-sectional study: Determinants of HBV Testing and Vaccination. J Ideas Health [Internet]. 2026 Oct. 31 [cited 2026 Nov. 9];9(5):1473-9. Available from: https://jidhealth.com/index.php/jidhealth/article/view/462

References

1. World Health Organization. Global hepatitis report 2026. Geneva: World Health Organization; 2026. ISBN 978-92-4-012238-3.

2. World Health Organization. Global hepatitis report 2024: action for access in low- and middle-income countries. Geneva: World Health Organization; 2024. ISBN 978-92-4-009167-2.

3. Schmit N, Nayagam S, Thursz MR, Hallett TB. The global burden of chronic hepatitis B virus infection: comparison of country-level prevalence estimates from four research groups. Int J Epidemiol. 2021 May 17;50(2):560-569. doi: 10.1093/ije/dyaa253.

4. Conners EE, Panagiotakopoulos L, Hofmeister MG, Spradling PR, Hagan LM, Harris AM, et al. Screening and testing for hepatitis B virus infection: CDC recommendations—United States, 2023. MMWR Recomm Rep. 2023;72(1):1-25. doi:10.15585/mmwr.rr7201a1.

5. Weng MK, Doshani M, Khan MA, Frey S, Ault K, Moore KL, et al. Universal hepatitis B vaccination in adults aged 19-59 years: updated recommendations of the Advisory Committee on Immunization Practices—United States, 2022. MMWR Morb Mortal Wkly Rep. 2022;71(13):477-483. doi:10.15585/mmwr.mm7113a1.

6. Abesig J, Chen Y, Wang H, Sompo FM, Wu IXY. Prevalence of viral hepatitis B in Ghana between 2015 and 2019: a systematic review and meta-analysis. PLoS One. 2020;15(6):e0234348. doi:10.1371/journal.pone.0234348.

7. Ofori-Asenso R, Agyeman AA. Hepatitis B in Ghana: a systematic review and meta-analysis of prevalence studies (1995-2015). BMC Infect Dis. 2016;16:130. doi:10.1186/s12879-016-1467-5.

8. Osei E, Niyilapah J, Kofi Amenuvegbe G. Hepatitis B knowledge, testing, and vaccination history among undergraduate public health students in Ghana. Biomed Res Int. 2019;2019:7645106. doi:10.1155/2019/7645106.

9. Adjei Gyimah A, Peprah P, Agyemang-Duah W, Frimpong E, Kwegyir Tsiboe A, Aboagye Darkwa M. Hepatitis B vaccination status and associated factors among university students in Ghana: a cross-sectional survey. Cogent Med. 2021;8(1):2005226. doi:10.1080/2331205X.2021.2005226.

10. Aniaku JK, Amedonu EK, Fusheini A. Assessment of knowledge, attitude and vaccination status of hepatitis B among nursing training students in Ho, Ghana. Ann Glob Health. 2019;85(1):18. doi:10.5334/aogh.750.

11. Botchway ET, Agyare E, Seyram L, Owusu KK, Mutocheluh M, Obiri-Yeboah D. Prevalence and attitude towards hepatitis B vaccination among healthcare workers in a tertiary hospital in Ghana. Pan Afr Med J. 2020;36:244. doi:10.11604/pamj.2020.36.244.24085.

12. Senoo-Dogbey VE, Wuaku DA, Mumuni AA. Adherence to the three-component Hepatitis B virus vaccination protocol among healthcare workers in hepatitis B virus endemic settings in Ghana. Vaccine X. 2024;16:100421. doi:10.1016/j.jvacx.2023.100421.

13. Senoo-Dogbey VE, Anto F, Quansah R, Danso-Appiah A. Completion of three-dose hepatitis B vaccination cycle and associated factors among health care workers in the Greater Accra Region of Ghana. PLoS One. 2024;19(4):e0298771. doi:10.1371/journal.pone.0298771.

14. Senoo-Dogbey VE, Armah D, Wuaku DA. Hepatitis B virus vaccination post serological testing and antibody levels of vaccinated health care workers in Accra, Ghana. Vaccine X. 2023;14:100294. doi:10.1016/j.jvacx.2023.100294.

15. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP; STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007;4(10):e296. doi:10.1371/journal.pmed.0040296.

16. Yamane T. Statistics: an introductory analysis. 2nd ed. New York: Harper and Row; 1967.

17. Hair JF, Risher JJ, Sarstedt M, Ringle CM. When to use and how to report the results of PLS-SEM. Eur Bus Rev. 2019;31(1):2-24. doi:10.1108/EBR-11-2018-0203.